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New Report on Temporomandibular Disorders: Priorities for Research and Care

Over a year and half ago, the National Academy of Medicine (NAM) began the most comprehensive study ever undertaken on Temporomandibular Disorders (TMD). The study assessed the current state of TMD research, education and training, the safety and efficacy of clinical treatments, and associated burden and costs.

Statement by NIDCR Acting Director on the National Academies of Sciences, Engineering, and Medicine Report on Temporomandibular Joint Disorders

I am pleased to announce the release of the National Academies of Sciences, Engineering, and Medicine (NASEM) report, Temporomandibular Disorders: Priorities for Research and Care. As underscored by the comprehensive report, temporomandibular joint disorders (TMJDs) are a diverse and still poorly understood set of complex, painful conditions affecting the jaw muscles and tissues, temporomandibular joints, and associated nerves. Clearly, there is much more to be understood, and these conditions continue to confound medical and dental health care providers and researchers.

Have you seen the film Dark Waters?

The Film. Dark Waters is about attorney Robert Billott's real-life 20 year legal battle against DuPont chemical for releasing toxic waste - perfluorooctanoic acid, or PFOA - into Parkersburg, West Virginia's water supply, with devastating health effects on the townspeople and livestock. PFOA, also known as C8, is a man-made chemical. It is used in the process of making Teflon and similar chemicals known as fluorotelomers.

Online TMD Diet Diary Research Project

Online TMD Diet Diary Research Project The TMJ Association received the following request from Professor Justin Durham and his research team at Newcastle University. We encourage TMJ patients to participate in this project as it is an under researched

Drug Induced Bruxism

The authors of this article state that orofacial movement disorders (bruxism) are treated typically by dental professionals and not by those specialists (neurologists) researching and treating the other movement disorders (Parkinson's disease, Huntington's disease, tremors, etc.). Again, this is more evidence of the complexity of TMD and the need for multidisciplinary research and treatment in TMD.

Can Autoimmunity Cause Pain?

  • Jan 27, 2017

Immunity-Suppressing Drugs Often Relieve Pain Autoimmunity is a condition in which the body's immune system turns against its own tissues. Pain Research Forum, a website for the pain research community, recently highlighted several studies suggesting that some chronic pain may be associated with autoimmunity. Multiple sclerosis and rheumatoid arthritis are two examples of diseases caused by autoimmune reactions. The clinical studies found that some patients with chronic pain had antibodies (specialized cells of the immune system which can recognize organisms that invade the body such as bacteria, viruses, and fungi) in their blood against selected proteins on the membranes of their nerve cells. The membrane proteins in question are members of a family called voltage-gated potassium channel complex (VGKC-complex) and play an important role in regulating a nerve cell’s excitability. Autoantibodies directed against selected VGKC members could make cells in pain pathways hyperexcitable, causing pain or making existing pain worse. What’s more, when pain patients with autoantibodies were treated with drugs to suppress immunity, their pain symptoms (which varied from widespread to specific body sites such as the head or face) were often relieved. Exactly what triggers the autoimmune reaction, how the autoantibodies work and whether immune system cells themselves (which also have VGKC proteins on their surface) play a role, are among the many questions stimulating researchers in the field.

TMJ Disorders


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