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The Scoop on TMD Pharmaceuticals

Let's say the National Institutes of Health just handed us a multi-million dollar grant to get to the bottom of TMD and find a cure once and for all. I mean, we could start handing out heating pads left and right, but that kind of relief can only get us so far. Whenever I try a different form of therapy or medication, I like to think about the biology, right down to the cellular and molecular level. Why are the cells that make up my jaw region being such jerks?

Join Us AT TMJ Cafe

The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

Suzanne: Teen Awareness and Support

  • May 13, 2015

Suzanne is a teenager who wants desperately to live life free from pain and discomfort. TMJ symptoms have forced Suzanne to stop doing what most teenagers take for granted—hanging out with friends, going to school, and participating in sports and music.

Suzanne decided to do something to help herself and began researching TMJ diseases and disorders on the Internet. She discovered the Association’s website and was comforted to know that an organization existed that truly understood what she was going through.

Suzanne wrote, “I am 16 years old and have had TMJ since I was born. As I have gotten older, it has worsened. My jaw has started to give me a speaking problem and causes so much pain. I have to live with this pain because my parents don’t have health insurance, and we can’t afford major reconstructive surgery that will cost way over $30,000. My parents have struggled for years to get me as much help and comfort as they could. Now we are kind of at a halt with no money. I’ve seen so many doctors and have had so many opinions that all ended up the same. I am young, but if I can make it struggling in school with the pain and dislocation, I know other people can too. I hope that one day someone will find a cure, so I can actually be a kid for once and do things that I want to do, like sports and stuff. That is my one dream.

Suzanne hopes by sharing her story she can reassure teens and provide them a sense of comfort in knowing they are not alone and that there is hope.

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In Treating TMJ

To view or order a free booklet about TMJ Disorders, visit the National Institutes of Health website.

U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES
National Institutes of Health
National Institute of Dental and Craniofacial Research
Office of Research on Women's Health