Its purpose is to expand contemporary, systematic research approaches to elucidate the role of immune system plasticity in health and in the pathogenesis of dental, oral, and craniofacial (DOC) diseases. The goal is to advance knowledge of the immunological basis of dental, oral, and craniofacial diseases, and to develop tools and technologies for precise modulation of the immune system to restore or maintain health. The expectation is that new knowledge derived from this research will facilitate development of novel immunomodulatory therapies to prevent disease onset or reverse disease progression.
In orofacial pain, peripheral tissue damage or nerve injury stimulates local and systemic immune responses interfacing with the central nervous system (CNS), and this process is likely to be involved in the transition of acute to chronic pain as well as in the persistence of chronic pain
This program announcement is issued as a companion set: please see PAR-15-192 http://grants.nih.gov/grants/guide/pa-files/PAR-15-192.html for the R01 and PAR-15-193 http://grants.nih.gov/grants/guide/pa-files/PAR-15-193.html for the R21 activity codes. The first due dates are in October 2015.
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