Our 2016 TMJA online survey results show that 26% of respondents suffer from migraine
headaches; they are one of the overlapping chronic pain conditions associated with
Women who experienced a steeper decline in estrogen levels prior to menstruation
were more likely to experience migraines, researchers found.
In an analysis of data collected as part of the long-term longitudinal Study of Women's
Health Across the Nation (SWAN), migraineurs' urinary estrogens (E1c) declined in the
2 days before the period peak at a faster absolute rate than nonmigraineurs and at a
higher percent change than nonmigraineurs (40% versus 30%), Jelena Pavlovic, MD,
PhD, of the Albert Einstein College of Medicine in New York City, and colleagues
reported in Neurology. The study authors did not find significant differences in the
groups when they looked at absolute peak and daily hormone values, and they found
no significant differences in the time period around the ovulatory phase.
As part of a secondary analysis within the migraineurs' group, the authors determined
that hormone patterns were similar regardless of whether the woman had a migraine
that cycle. As a result, Pavlovic and her team formed a "two-hit" hypothesis in which
women with rapid estrogen level dips before menstruation are more sensitive to
migraine triggers, such as stress, lack of sleep or a glass of wine. It's a combination of
the estrogen drop and the additional triggers that result in a migraine.
Read full article at:http://www.medpagetoday.com/clinical-context/Migraines/58267