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The Scoop on TMD Pharmaceuticals

Let's say the National Institutes of Health just handed us a multi-million dollar grant to get to the bottom of TMD and find a cure once and for all. I mean, we could start handing out heating pads left and right, but that kind of relief can only get us so far. Whenever I try a different form of therapy or medication, I like to think about the biology, right down to the cellular and molecular level. Why are the cells that make up my jaw region being such jerks?

Join Us AT TMJ Cafe

The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

#*!"@!**! ... May Help Your Pain... and Improve Strength!

  • May 31, 2017

Our headline is adopting the comic strip convention of using symbols to denote swear words because we are intrigued by a report that swearing may have some health benefits. Certainly in our personal lives, we all have felt the satisfaction of exclaiming some forbidden expletive when hitting our thumb with a hammer or as a way of relieving the deep frustration we experience after standing in line and when you reach the box office discovering that the show you wanted to see is sold out. But as a way to reduce pain? and increase strength? Well maybe...

Psychology investigators at Britain's Keele University have conducted a series of investigations in which they found that swearing made individuals more tolerant of pain. They went on to test whether swearing also increased individuals' ability to perform intense exercise and also deepened the strength of their handgrips. 

They tested 29 people in an intense anaerobic exercise regimen and found that their power increased after they had used swear words at the outset compared with the same exercise conducted without swearing. Similarly, in a test of handgrip strength of 52 participants, they found that their grips were stronger following a bout of swearing compared with not swearing.

The investigators initially surmised that swearing stimulates the body's sympathetic nervous system-the fight-or-flight mechanism that increases heart rate and affects energy metabolism, among other things. But when they looked for typical sympathetic system changes they found nothing significant. So now it's back to the drawing board to search for answers. But their findings still hold.

Overlapping Conditions

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