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The Scoop on TMD Pharmaceuticals

Let's say the National Institutes of Health just handed us a multi-million dollar grant to get to the bottom of TMD and find a cure once and for all. I mean, we could start handing out heating pads left and right, but that kind of relief can only get us so far. Whenever I try a different form of therapy or medication, I like to think about the biology, right down to the cellular and molecular level. Why are the cells that make up my jaw region being such jerks?

Join Us AT TMJ Cafe

The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

Beware of Ticks and Lyme Disease

  • Jun 1, 2017

We are currently in the peak season for Lyme disease. Each year at this time we highlight this topic because we have heard from a number of patients over the years who were misdiagnosed and underwent unnecessary TMD treatments when they actually had Lyme disease.

Lyme disease symptoms often mimic those of TMD. The TMJ Association encourages patients who think they may have TMD to be sure to talk to their medical doctor in order to rule out other conditions which could be the cause their symptoms. Especially with Lyme disease, early diagnosis and treatment are important.

Lyme disease can cause fever, headaches, fatigue, and a characteristic skin rash. Left untreated, infection can spread to joints, the heart, and the nervous system. Permanent damage to the joints or the nervous system can develop in patients with late Lyme disease.

Other symptoms of early Lyme disease include:

  • migratory muscle and joint aches
  • headache
  • chills and fever
  • fatigue
  • swollen lymph nodes

Other symptoms may not appear until weeks or months after a tick bite occurs. They include:

  • arthritis (usually as pain and swelling in large joints, especially the knee)
  • nervous system abnormalities
  • heart-rhythm irregularities

This year health officials are also warning of another virus called Powassan which is transmitted by the bite of infected deer/blacklegged tick, the same tick that causes other tickborne diseases, including Lyme disease. Powassan causes nonspecific flu-like symptoms including muscle aches and pains, a small skin rash, and fever and headache. 

Read some of our patient stories related to Lyme disease:

TMJ Disorders

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