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The Scoop on TMD Pharmaceuticals

Let's say the National Institutes of Health just handed us a multi-million dollar grant to get to the bottom of TMD and find a cure once and for all. I mean, we could start handing out heating pads left and right, but that kind of relief can only get us so far. Whenever I try a different form of therapy or medication, I like to think about the biology, right down to the cellular and molecular level. Why are the cells that make up my jaw region being such jerks?

Join Us AT TMJ Cafe

The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

Kolia

  • Dec 21, 2017

I am 36 years old and have been living with Temporomandibular Disorders (TMD) and was diagnosed with Trigeminal Neuralgia in 2008.  

My TMD diagnosis was made in 2006. I have been to numerous dental and maxillofacial professionals over the years. Insurance coverage limits my treatments. I have gone through multiple root canals and teeth replacements on my right joint, which is where all of my nerve and joint pain occurs. I have a droop in my face and often my muscle contracts on my right side. I frequently have my joint pop out of socket, and often have to hold it in while eating, yawning etc. I prefer to eat alone due to the noise and the fact that holding my joint is embarrassing.  

I have worked a very tough corporate job for the past 11 years, and I have always been hesitant about jaw replacement surgery, despite my provider's recommendation. I am looking forward to having children at this point, because of the ages of me and my spouse, and hope that shortly after having children I could commit to surgical interventions. I have had injections, bone grafts, etc.  

I am beyond grateful for the resources and the personal stories provided on www.tmj.org. Thank you all.  


In Treating TMJ

To view or order a free booklet about TMJ Disorders, visit the National Institutes of Health website.

U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES
National Institutes of Health
National Institute of Dental and Craniofacial Research
Office of Research on Women's Health