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National Academy of Medicine to Conduct a Study on Temporomandibular Disorders

We want you to be among the first to know that because of the advocacy efforts of The TMJ Association, the National Academy of Medicine (NAM) will conduct a first-ever study on Temporomandibular Disorders (TMD).

Dentists in Distress

Fear of the dentist is practically a rite of passage in youth. Growing up, I wasn't exactly afraid of the dentist; rather, any excuse to leave school early was a powerful incentive. These days, I have a more complicated relationship with dentistry: I go to get answers and try to feel better, but I always pop a prophylactic ibuprofen or two in case my jaw protests from the oral gymnastics.

Patients in Los Angeles or New York City Needed for Clinical Study - Comparative Study of Women Considering or Currently Receiving Botox© Injections for TMJ Pain

Are you a woman with "TMJ" pain in facial muscles, who has either: a. recently had Botox© injections for your pain or b. not had Botox© for your pain but has thought about such treatment? If either is true for you, you may qualify for an observational research study centrally administered by the NYU College of Dentistry. It is funded by the National Institutes of Health (NIH). The purpose of this study is to understand potential health risks that may be caused by treating "TMJ pain" with Botox© injections.

Patients Front and Center at the 2018 TMJ Patient-Led RoundTable

It is still all too fresh in the minds of many patients. Fifty years ago, between the 1970s and 1980s, some 10,000 TMJ patients received Vitek jaw implant devices.

Funding Opportunities now available for the NIH Common Fund’s Acute to Chronic Pain Signatures program

The NIH Common Fund's Acute to Chronic Pain Signatures program aims to understand the biological characteristics underlying the transition from acute to chronic pain and what makes some people susceptible and others resilient to the development of chronic pain.

Hyperreactive Brain Network May Be Cause of Chronic Pain in Fibromyalgia, Study Suggests

  • Feb 14, 2018

Fibromyalgia is one of the overlapping pain conditions with TMD. This article appeared in Fibromyalgia News Today on January 15, 2018.

A new study suggests a hyperreactive brain network may be the underlying cause of chronic pain in fibromyalgia. The study, "Functional Brain Network Mechanisms of Hypersensitivity in Chronic Pain," was published in the journal of Scientific Reports.

The report shows that brain networks of fibromyalgia patients have an underlying hypersensitivity that leads them to overreact to stimulation in an explosive, widespread, and synchronized manner.

This type of response is called explosive synchronization (ES), a phenomenon that occurs both in biological and technological networks, such as during epileptic seizures or power grid failures.

"For the first time, this research shows that the hypersensitivity experienced by chronic pain patients may result from hypersensitive brain networks," Richard Harris, the study's co-senior author and associate professor of anesthesiology at the Chronic Pain and Fatigue Research Center at Michigan Medicine, said in a press release.

The electrical activity of the brains of 10 female fibromyalgia patients were recorded by electroencephalogram (EEG), a noninvasive technique.

EEG results revealed that fibromyalgia patients do indeed display brain network configurations with explosive synchronization properties. In each patient, researchers found a significant correlation between the degree of ES and the intensity of reported chronic pain.

Researchers then used computer models of brain activity to simulate how a fibromyalgia brain reacts to stimulation. They found that the fibromyalgia brain was more sensitive to electrical stimulation than a brain model without ES characteristics.

"As opposed to the normal process of gradually linking up different centers in the brain after a stimulus, chronic pain patients have conditions that predispose them to linking up in an abrupt, explosive manner," said UnCheol Lee, the study's first author, a physicist and assistant professor of anesthesiology at Michigan Medicine.

According to the team, this type of modeling could help guide future treatments for fibromyalgia as brain regions important for explosive synchronization behavior and therapies that target it can first be tested on a computer model.

It is still unknown from a global brain perspective which of the brain network interactions create the subjective sensation of chronic pain. This study suggests, for the first time, that the explosive synchronization phenomena might be the cause of chronic pain in fibromyalgia patients.

Overlapping Conditions

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