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The Scoop on TMD Pharmaceuticals

Let's say the National Institutes of Health just handed us a multi-million dollar grant to get to the bottom of TMD and find a cure once and for all. I mean, we could start handing out heating pads left and right, but that kind of relief can only get us so far. Whenever I try a different form of therapy or medication, I like to think about the biology, right down to the cellular and molecular level. Why are the cells that make up my jaw region being such jerks?

Join Us AT TMJ Cafe

The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

Dry Eye Linked to Chronic Overlapping Pain in Veteran Population

  • Feb 14, 2018

The following article appeared in MD Magazine, November 13, 2017

There may be a correlation between dry eye (DE) and chronic pain in the US military veteran population as is evident by a recent study.

In a retrospective review of Florida veteran's medical records between 2010 and 2014, researchers found an association between severe DE symptoms and non-ocular pain. They also found that individuals with chronic overlapping pain conditions (COPC) had more severe DE symptoms, but similar ocular surface signs.

The study, led by Charity J. Lee, from the Miami Veterans Administration Medical Center and Bascom Palmer Eye Institute at the University of Miami, was presented at the 121st Annual Meeting of the American Academy of Ophthalmology (AAO 2017) in New Orleans, LA.

Chronic pain, as defined by the researchers as a pain that persists beyond expected resolution - or about 3 months - is prevalent in 116 million US adults.

Lee explained that COPC is common among non-ocular conditions, including back pain, migraines, and fibromyalgia. DE, a multifactorial disease, affects about 15% of US citizens.

Of the approximate 3.2 million patients seen at Veterans Affairs (VA) hospitals between the studied years, DE was diagnosed in 959,881 (29.4%) patients. Another 854,480 (26.2%) were diagnosed with tear film dysfunction (TFD), and 186,299 (5.7%) were diagnosed with ocular pain. Less than 3% of patients had the latter 2 diagnoses together, Lee said.

Researchers also found that patients were more likely to be diagnosed with DE with the more chronic pain condition diagnoses they had. The 422 patients diagnosed with 13 or more chronic pain conditions had at least an 80% chance of being diagnosed with DE as well.

Ocular pain was most strongly associated with headaches, tension headaches, migraines, temporomandibular joint disorders, pelvic pain, central pain syndrome, and fibromyalgia in the veteran patient population, Lee said.

Lee proposed that sensations of dryness in some patients could be a local manifestation of a system-wide diagnosis of chronic pain. She also noted there are few treatment options for DE and multi-disciplinary chronic pain care patients.

Accordingly, panel members at AAO 2017 suggested the next course of research focus on possibly using systemic treatment for DE and COPC.

"Since they tend to coexist together, I think that broad treatment may definitely have an effect, not only with dry eye, but with the rest of the pain conditions that come along with it," Lee said. 

Overlapping Conditions


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