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Swallowing Changes Related to Chronic Temporomandibular Disorders

To investigate whether chronic temporomandibular disorder (TMD) patients showed any changes in swallowing compared to a control group. Moreover, it was examined whether swallowing variables and a valid clinic measure of orofacial myofunctional status were associated.

National Academy of Medicine Holds Second TMD Meeting

We have reported previously about the decision of the prestigious National Academy of Medicine (NAM) to convene a committee of experts to examine all aspects of temporomandibular disorders (TMD).

What Does Blood Pressure Have to Do with Chronic Pain?

To understand this possible connection, you have to consider how blood pressure is normally controlled by the nervous system.

Committee on Temporomandibular Disorders (TMD): From Research Discoveries to Clinical Treatment

Public Workshop Committee on Temporomandibular Disorders (TMD): From Research Discoveries to Clinical Treatment

National Academy of Medicine Study on Temporomandibular Disorders: From Research Discoveries to Clinical Treatment

An ad hoc committee, under the auspices of the National Academies of Sciences, Engineering, and Medicine's Health and Medicine Division, has been convened to study temporomandibular disorders (TMD) in a project entitled From Research Discoveries to Clinical Treatment.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

  • May 30, 2018

The following was published in the March 2018 issue of Pain. This research was conducted by Guan Yun Frances Wang; Xiang Qun Shi; Wenjia Wu; Maria Gueorguieva; Mu Yang; Ji Zhang, Faculty of Dentistry, McGill University, Montreal, QC, Canada.  

Abstract: Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.  

Here, we report a novel mouse model of TMD where a bite block was placed in between the upper and lower incisors such that the mouth was kept maximally open for 1.5h per day for 5 days. Following sustained mouth opening, mice developed persistent orofacial mechanical allodynia and TMJ dysfunction. At the cellular level, we found masseter muscle dystrophy, and increased proteoglycan deposition and hypertrophic chondrocytes in the mandibular condyle. Increased F4/80 macrophages were also observed in the masseter muscles and the TMJ posterior synovium. We also found ATF3 neuronal injury and increased F4/80 macrophages in the trigeminal ganglia. Microglia activation was observed in the trigeminal subnucleus caudalis. Inhibiting macrophage/microglia activation with a colony stimulating factor-1 receptor inhibitor prevented the development of orofacial mechanical allodynia, but not TMJ dysfunction.

This study suggests that mouth opening for an extended period of time during dental treatments or oral intubations may risk the development of chronic TMD and inflammation associated with macrophage/microglia in the tissue and trigeminal system contributes to the development of TMD pain. 

TMJ Disorders

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