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The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

Centralized Pain in TMD: Is It All in the Head?

We are pleased to introduce Sophia Stone, a new contributor to The TMJ Association, whose passion is to separate TMD fact from TMD fiction. Sophia has a background in medicine and research and can draw on her personal experience as a TMD patient.

ADVISORY BOARD

  • Dec 21, 2017

Allen W. Cowley, Jr., Ph.D.
Scientific Advisory Council Chairman
James J. Smith & Catherine Welsh Smith Professor in Physiology
Harry & Gertrude Hack Term Professor in Physiology
Professor and Chairman, Physiology Director of the Cardiovascular
Center
Medical College of Wisconsin
Milwaukee, WI

Kyriacos A. Athanasiou, Ph.D., P.E.
Distinguished Professor
Chair, Department of Biomedical Engineering
University of California Davis
Davis, CA

Allan Basbaum, Ph.D.
Professor and Chair, Department of Anatomy
University of California, San Francisco
San Francisco, CA

David B. Burr, Ph.D.
Professor of Biomedical Engineering
Professor and Chairman of Anatomy and Cell Biology
Professor of Orthopedic Surgery
Indiana University School of Medicine
Indianapolis, IN

Christine B. Chung, M.D.
Associate Professor in Residence
Department of Radiology
University of California, San Diego
San Diego, CA 

Daniel J. Clauw, M.D.
Professor, Pain Management Anesthesiology
University of Michigan
Ann Arbor, MI

Ronald Dubner, D.D.S., Ph.D.
Professor, Department of Neural and Pain Sciences
University of Maryland
Baltimore, MD

Martin Frank, Ph.D.
Executive Director
American Physiological Society
Bethesda, MD

Howard J. Jacob, Ph.D.
HudsonAlpha Institute for Biotechnology
Huntsville, AL

Jon D. Levine, M.D., Ph.D.
Faculty, Neuroscience Graduate Program
University of California
San Francisco, CA

Alan R. Light, Ph.D.
Professor of Anesthesiolgy, Neurbiology and Anatomy
University of Utah
Salt Lake City, UT

Richard B. Lipton, M.D.
Edwin S. Lowe Professor and Vice Chair of Neurology,
Professor of Epidemiology and Population Health and
Professor of Psychiatry and Behavioral Sciences
Albert Einstein College of Medicine
Bronx, NY

Sean Mackey, M.D., Ph.D.
Chief of the Division of Pain Medicine and Redlich Professor
of Anesthesiology, Perioperative and Pain Medicine,
Neurosciences and Neurology
Stanford University
Redwood City, CA

William Maixner, D.D.S., Ph.D.
Professor of  Anesthesiology
Anesthesiology / Center for Translational Pain Medicine
Duke University School of Medicine
Durham, NC

Emeran A. Mayer, M.D.
Professor in the Departments of Medicine, Physiology and
Psychiatry & Biobehavioral Sciences
University of California, Los Angeles
Los Angeles, CA

Ruby H.N. Nguyen, Ph.D.
Associate Professor, Epidemiology & Community Health
University of Minnesota
Minneapolis, MN

Philip A. Pizzo, M.D.
David and Susan Heckerman Professor and
Professor of Microbiology and Immunology
Stanford University
Stanford, CA

Anthony Ratcliffe, Ph.D.
President & CEO
Synthasome, Inc.
San Diego, CA

Christian S. Stohler, D.M.D., Dr. Med. Dent.
Dean, Columbia University College of Dental Medicine
New York, NY

Suzanne D. Vernon, Ph.D.
Scientists
Bateman Horne Center of Excellence
Salida, CO

John T. Watson, Ph.D.
Associate Director, VonLiebig Center
Professor Bioengineering
University of California San Diego
La Jolla, CA

Ursula Wesselmann, M.D., Ph.D.
Professor, Division of Pain Medicine
University of Alabama at Birmingham
Birmingham, AL

Denniz Zolnoun, M.D., M.P.H. 
Associate Professor, Invasive Gynecologic Surgery
Director, Vulvar Clinic
University of North Carolina, Chapel Hill
Chapel Hill, NC

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In Treating TMJ

To view or order a free booklet about TMJ Disorders, visit the National Institutes of Health website.

U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES
National Institutes of Health
National Institute of Dental and Craniofacial Research
Office of Research on Women's Health