Read the Latest News

Hyperreactive Brain Network May Be Cause of Chronic Pain in Fibromyalgia, Study Suggests

Fibromyalgia is one of the overlapping pain conditions with TMD. This article appeared in Fibromyalgia News Today on January 15, 2018. A new study suggests a hyperreactive brain network may be the underlying cause of chronic pain in fibromyalgia.

Dry Eye Linked to Chronic Overlapping Pain in Veteran Population

There may be a correlation between dry eye and chronic pain in the US military veteran population as is evident by a recent study. Ocular pain was most strongly associated with headaches, tension headaches, migraines, temporomandibular joint disorders, pelvic pain, central pain syndrome, and fibromyalgia in the veteran patient population.

Patients in Los Angeles or New York City Needed for Clinical Study - Comparative Study of Women Considering or Currently Receiving Botox© Injections for TMJ Pain

Are you a woman with "TMJ" pain in facial muscles, who has either: a. recently had Botox© injections for your pain or b. not had Botox© for your pain but has thought about such treatment? If either is true for you, you may qualify for an observational research study centrally administered by the NYU College of Dentistry. It is funded by the National Institutes of Health (NIH). The purpose of this study is to understand potential health risks that may be caused by treating "TMJ pain" with Botox© injections.

Why Head and Face Pain Cause More Suffering

Hate headaches? The distress you feel is not all in your -- well, head. People consistently rate pain of the head, face, eyeballs, ears and teeth as more disruptive, and more emotionally draining, than pain elsewhere in the body.

Migraine and Coronary Artery Disease: A Genetic Connection

There has long been as association between migraine headaches and vascular (blood vessel) dysfunction of some kind, underscored by epidemiological studies and other research. New evidence for a genetic connection now comes from the analysis of several large data sets of each condition based on Genome Wide Association Studies (GWAS).

Are TMD Patients More Pain Sensitive? Maybe. But It's Complicated

  • Dec 16, 2016

TMD patients come in many different varieties. Some experience pain and dysfunction confined only to the jaw and/or the associated chewing muscles. Other TMD patients have jaw pain plus one or more other painful conditions elsewhere in the body. Scientists have been trying to figure out if these differences in their experience of pain reflect any long-term changes in the brain, in particular a phenomenon called "central sensitization," in which individuals become more sensitive to pain over time. Although "central sensitization" is considered a normal phenomenon, pain sensitive individuals may have brain changes that may make their pattern of central sensitization different than that of individuals without chronic pain.

To test for central sensitization, researchers typically use a 'temporal summation' method, in which volunteers are exposed to a nonpainful stimulus that becomes painful with repeated exposures to it. You might make an analogy to water dripping on rock that over time eventually penetrates the rock. In the temporal summation method used in the TMD experiment described below, volunteers were exposed to a heated pad placed on their palms for multiple times over a fixed time period. Individuals experiencing central sensitization would feel the heated pad becoming painful over time.

It is widely believed that individuals with fibromyalgia (widespread pain with diffuse tender points that are painful when lightly pressed) and perhaps some other pain conditions, including TMD, experience enhanced central sensitization, demonstrated either by reaching peak pain earlier in the temporal summation test or perhaps by having more lasting 'aftersensations' following removal of the heat. In a study conducted at New York University by Dr. Karen Raphael in collaboration with other institutions, researchers compared experimental pain sensitivity in three groups: patients with only muscle-based TMD (n=100), patients with TMD plus fibromyalgia (n=26), and a matched pain-free control group (n=48). Their surmise was that the TMD patients with fibromyalgia would have different pain sensitivity than TMD patients whose pain was confined to the chewing muscles or normal controls.

Results: Surprisingly, when the researchers looked at each individual participant, temporal summation did not often occur as expected, and rates of summation did not differ among participants in different groups. Even at the highest constant temperatures considered safe to test, less than half of participants showed an increase in subjective painfulness of the heated pad over repeated presentations. Participants were more likely to either rate the heat as having a consistent painfulness over time or, for some, even a reduction in painfulness. Examining just those participants who appeared to become centrally sensitized, the rate and pattern of central sensitization did not differ among any of the study groups. However, the subgroups of TMD patients had longer-lasting painful aftersensations than controls when the heated pad was removed. TMD patients with fibromyalgia had similarly painful aftersensations to those TMD patients without fibromyalgia.

Conclusions: This study shows that some of the methods used to assess pain sensitivity do not work as researchers expect. However, the problems may be obscured when averaging responses across all participants in a group. Nevertheless, since TMD patients had more lingering painful aftersensations when the heated pad was removed, the researchers were able to support the concept that TMD patients, both those with and without fibromyalgia, have some form of disturbance of central nervous system-managed pain processing mechanisms.

TMJ Disorders

Comments:

Login or Register to add Comment