A study published in the December 2024, issue of PAIN by Son H, Shannonhouse J, Zhang Y, et al., “Elucidation of neuronal activity in mouse models of temporomandibular joint injury and inflammation by in vivo GCaMP Ca2+ imaging of intact trigeminal ganglion neurons” offers promising insights into how nerve cells may be driving jaw pain in Temporomandibular Disorders (TMDs).
Researchers used an advanced imaging technique, GCaMP calcium imaging, to monitor the activity of trigeminal ganglion neurons—the nerve cells that carry pain signals from the face—in live mice following jaw joint injury and inflammation. This allowed them to observe how these cells respond to jaw damage in real time.
What They Found
- Jaw injury and inflammation led to increased and abnormal nerve activity.
- These changes may help explain why some people experience long-lasting or heightened jaw pain.
Why It Matters
By understanding the specific nerve responses involved in TMDs, scientists can work toward developing more targeted, effective treatments that go beyond managing symptoms—and instead address the root cause of the pain.